English to Spanish Science Genetics

Estoy traduciendo un artículo titulado: "Selective Inhibition of Inflammatory Gene Expression in Activated T Lymphocytes: A Mechanism of Immune Suppression by Thiopurines".

"AZA or 6-MP therapy results in accumulation of 6-TGN in lymphocytes. In the presence of T cell activation, as occurs in **immunologically driven diseases**, 6-TGN blocks the expression of TRAIL, TNFRS7, and α4-integrin, effects that functionally decrease inflammation. These findings provide a new framework for understanding thiopurine-mediated immunosuppression, and further studies will establish the specific roles of these gene products in mediating the beneficial effects of AZA and 6-MP in immune diseases."

AZA = azatioprina
6-TGN = nucleótidos de 6-tioguanina
TRAIL = ligando inductor de la apoptosis relacionado con el factor de necrosis tumoral
TNFRS7 = miembro 7 de la superfamilia de receptores del TNF
6-MP = 6-mercaptopurina

Muchas gracias por adelantado por sus sugerencias