Glossary entry (derived from question below)
English term or phrase:
AAV packaging gene
Serbian translation:
gen zadužen za pakovanje tj. sklapanje adenoviralne čestice
Added to glossary by
Svetomir Mijovic
Dec 13, 2022 11:45
1 yr ago
8 viewers *
English term
Serbia
Experienced Sci/Tech translator
Native in: Serbian 
, Serbo-Croat (Variant: Serbian)
Works in: Serbo-Croat to English, English to Bosnian, English to Croatian, and 1 more.
AAV packaging gene
English to Serbian
Medical
Medical: Pharmaceuticals
fusion proteins
In yet another aspect, the invention provides a method of producing an rAAV particle, comprising (a) culturing a host cell under a condition that rAAV particles are produced, wherein the host cell comprises (i) one or more AAV package genes, wherein each said AAV packaging gene encodes an AAV replication or encapsidation protein; (ii) an rAAV pro-vector comprising a nucleotide encoding any of the fusion proteins of the invention flanked by at least one AAV ITR, and (iii) an AAV helper function; and
Proposed translations
(Serbian)
| 3 | gen zadužen za pakovanje tj. sklapanje adenoviralne čestice |
Nebojša Mihaljević
|
Proposed translations
23 days
Nebojša Mihaljević
Montenegro
Montenegro
Native in Serbian
Montenegro
Translator & Electronic Engineer
Native in: Serbian (Variant: Montenegrin ) 
, Montenegrin
Works in: English to Serbian, English to Montenegrin, English to Serbo-Croat, and 6 more.
Related KudoZ points
:
52
Selected
gen zadužen za pakovanje tj. sklapanje adenoviralne čestice
Reference:
1. https://rektorat.unios.hr/molekularna/dokumenti/storage/zavr...
Na svojim krajevima DNA adenovirusa ima cis-djelujuće obrnuto ponavljajuće sljedove (engl. inverted terminal repeats, ITR) koji su potrebni za replikaciju adenoviralne DNA. U blizini lijevog ITR nalazi se cis-djelujući slijed za pakiranje (ψ) nužan za enkapsidaciju adenoviralne DNA. Ovisno o tome eksprimiraju li se prije ili nakon početka DNA replikacije, geni su podijeljeni na rane i kasne. U rane gene spada šest transkripcijskih jedinica: E1A, E1B, E2A, E2B, E3 i E4, čiji proteinski produkti omogućavaju replikaciju adenoviralne DNA. Kasni geni eksprimiraju se sa zajedničkog glavnog kasnog promotora (engl. major late promoter, MLP), čija premRNA podliježe alternativnom prekrajanju i diferencijalnoj poliadenilaciji rezultirajući s 5 kasnih transkripcijskih jedinica (L1, L2, L3, L4, L5). Kasni geni kodiraju za strukturne proteine adenovirusa kao i za proteine koji sudjeluju u sklapanju novih adenoviralnih
čestica.
2. https://repository.fzsri.uniri.hr/islandora/object/fzsri:965...
Proteini kasne regije zaduženi su za pravilno pakiranje virusnih čestica i omogućavanje izlaska virusne čestice.
1. https://rektorat.unios.hr/molekularna/dokumenti/storage/zavr...
Na svojim krajevima DNA adenovirusa ima cis-djelujuće obrnuto ponavljajuće sljedove (engl. inverted terminal repeats, ITR) koji su potrebni za replikaciju adenoviralne DNA. U blizini lijevog ITR nalazi se cis-djelujući slijed za pakiranje (ψ) nužan za enkapsidaciju adenoviralne DNA. Ovisno o tome eksprimiraju li se prije ili nakon početka DNA replikacije, geni su podijeljeni na rane i kasne. U rane gene spada šest transkripcijskih jedinica: E1A, E1B, E2A, E2B, E3 i E4, čiji proteinski produkti omogućavaju replikaciju adenoviralne DNA. Kasni geni eksprimiraju se sa zajedničkog glavnog kasnog promotora (engl. major late promoter, MLP), čija premRNA podliježe alternativnom prekrajanju i diferencijalnoj poliadenilaciji rezultirajući s 5 kasnih transkripcijskih jedinica (L1, L2, L3, L4, L5). Kasni geni kodiraju za strukturne proteine adenovirusa kao i za proteine koji sudjeluju u sklapanju novih adenoviralnih
čestica.
2. https://repository.fzsri.uniri.hr/islandora/object/fzsri:965...
Proteini kasne regije zaduženi su za pravilno pakiranje virusnih čestica i omogućavanje izlaska virusne čestice.
4 KudoZ points awarded for this answer.
Comment: "Hvala!"
Reference comments
33 mins
Reference:
AAV =
Adeno-associated virus (AAV) Guide - Addgene
https://www.addgene.org › guides › aav
The short coding sequences of channelrhodopsins, halorhodopsins, and other optogenetic genes enables them to be packaged in AAVs. Click here for more ...
--------------------------------------------------
Note added at 37 minutes (2022-12-13 12:22:53 GMT)
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I can only find this:
mediated gene replacement therapy for neurological disorders
https://eprints.whiterose.ac.uk › Circumventing th...
PDF
by L Marrone · 2022 · Cited by 3 — While the ITRs allow the replication and ***packaging of the AAV genome***, rep encodes the four proteins required for replication (Rep40, Rep52, ...
https://www.addgene.org › guides › aav
The short coding sequences of channelrhodopsins, halorhodopsins, and other optogenetic genes enables them to be packaged in AAVs. Click here for more ...
--------------------------------------------------
Note added at 37 minutes (2022-12-13 12:22:53 GMT)
--------------------------------------------------
I can only find this:
mediated gene replacement therapy for neurological disorders
https://eprints.whiterose.ac.uk › Circumventing th...
by L Marrone · 2022 · Cited by 3 — While the ITRs allow the replication and ***packaging of the AAV genome***, rep encodes the four proteins required for replication (Rep40, Rep52, ...
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