Glossary entry

Russian term or phrase:

ТАНДЕМНЫХ ПОЛИМОРФНЫХ ПОВТОРОВ

English translation:

polymorphic tandem repeats

Added to glossary by Frank Szmulowicz, Ph. D.
Oct 7, 2017 11:32
6 yrs ago
Russian term

ТАНДЕМНЫХ ПОЛИМОРФНЫХ ПОВТОРОВ

Russian to English Medical Genetics
ГЕНЕТИЧЕСКАЯ ИДЕНТИФИКАЦИЯ ВЫДЕЛЕННЫХ ДНК МЕТОДОМ ПОЛИМЕРАЗНОЙ ЦЕПНОЙ РЕАКЦИИ (ПНР) С ИСПОЛЬЗОВАНИЕМ В КАЧЕСТВЕ МАРКЕРОВ ТАНДЕМНЫХ ПОЛИМОРФНЫХ ПОВТОРОВ ДНК ВОСЕМНАДЦАТИ ТЕСТ-СИСТЕМ: AME. CSF1PO, D10S1248
Proposed translations (English)
3 +3 polymorphic tandem repeats
Change log

Oct 12, 2017 09:38: Frank Szmulowicz, Ph. D. Created KOG entry

Discussion

Vertrad (asker) Oct 7, 2017:
Thanks a lot!
A loop would be a circle. Here, nucleotides are arranged linearly in a row.
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A Short Tandem Repeat (STR) analysis is one of the most useful methods in molecular biology which is used to compare specific loci on DNA from two or more samples. A short tandem repeat is a microsatellite, consisting of a unit of two to thirteen nucleotides repeated hundreds of times in a row on the DNA strand. STR analysis measures the exact number of repeating units. This method differs from restriction fragment length polymorphism analysis (RFLP) since STR analysis does not cut the DNA with restriction enzymes. Instead, probes are attached to desired regions on the DNA, and a polymerase chain reaction (PCR) is employed to discover the lengths of the short tandem repeats.

https://en.wikipedia.org/wiki/STR_analysis
Vertrad (asker) Oct 7, 2017:
Has 'repeat' here the meaning of 'loop'? Thanks

Proposed translations

+3
9 mins
Selected

polymorphic tandem repeats

Tandem repeats occur in DNA when a pattern of one or more nucleotides is repeated and the ... Polymorphic tandem repeats (alias VNTRs) are also present in
https://en.wikipedia.org/wiki/Tandem_repeat

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Note added at 12 mins (2017-10-07 11:45:26 GMT)
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Polymorphic tandem repeats within gene promoters act as modifiers of gene expression and DNA methylation in humans
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857002/
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Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers.
https://www.ncbi.nlm.nih.gov/pubmed/10652619
Note from asker:
Frank, I am trying to figure out the Romanian version of this term. Has 'repeat' here the meaning of 'loop'? Thanks
Peer comment(s):

agree Andrey Svitanko
8 mins
Thank you, Andrey. Have a great weekend!
agree Turdimurod Rakhmanov
36 mins
Thank you, Turdimurod. Have a nice day!
agree 5555555 (X) : That was the first thing that popped into my mind.
1 hr
Thank you, Kimberly
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4 KudoZ points awarded for this answer. Comment: "Spasibo!"
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