английский => русский Наука Биология (биотехника, биохимия, микробиология)

when comparing the functional characteristics of exemplary bispecific antigen-binding constructs, the reference antigen-binding construct may be a trastuzumab analog such as, for example v506, or may be a combination of antibodies such as trastuzumab and pertuzumab (v4184). In embodiments where the format of the bispecific antigen-binding construct is being compared, the reference antigen-binding construct is, e.g., a biparatopic anti-HER2 antibody where both antigen-binding moieties are in the Fab-Fab format (format reference antigen-binding construct). Examples of the latter construct include v6902 and v6903.


In one embodiment, the bispecific antigen-binding construct is in a Fab-scFv format and induces greater HER2 internalization than a "format reference antigen-binding construct" that is in a Fab-Fab format in cells expressing HER2 at the 3+ level
In one embodiment, the bispecific antigen-binding construct is in a Fab-scFv format and induces greater HER2 internalization than "a format reference antigen-binding construct" that is in a Fab-Fab format in cells expressing HER2 at the 2+ or 3+ level.

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